Dekakute Ecchi na Ore no Ane(2013)

デカくてエッチな俺の姉

After a long absence, Shunsuke returns home at the invitation of his older sisters. He learns that his sisters suffer from a rare condition: they have abnormally strong sexual desires resulting from a disease. Now, Shunsuke must do whatever he can to improve their health. (This OVA is based on the erotic game by Marine.)